What the manual says
Manufacturer manualLack of communication with the remote connected to zone 2.
From this model's manual
Verified against the Biasi Inovia 2020 Combi installation & service manual.
DIY fix possible
Check if the batteries in your Zone 2 room thermostat need replacingEnsure the remote control or thermostat is within range of the boilerCheck for any wireless interference from other electronic devices near the receiver
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